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Single-channel recording of ΔR/E1371S-CFTR in the presence of 10 μM ATP. (A) A continuous 45-min single-channel trace in the presence of 10 μM ATP. Note that the channel remains closed for long periods, and presents opening bursts of different lengths. (B) Expanded traces of selected parts of the trace in A. Note the presence of very brief openings (*), and intermediate locked-open events (**), and rarely occurring long locked-open events (***).
