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Kinetic analysis of the last E1371S-CFTR channel that remains open after removal of ATP. (A) Sample trace of the current relaxation of E1371S-CFTR channels upon ATP washout. The inset shows the expanded trace of the last channel that remains open. Note the presence of poorly resolved flickers and several long closings that last for hundreds of milliseconds. (B) Data from four patches were pooled together to construct the closed time histogram.
