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. Author manuscript; available in PMC: 2012 Mar 19.
Published in final edited form as: J Neurosci. 2007 Jul 25;27(30):7899–7910. doi: 10.1523/JNEUROSCI.1396-07.2007

Figure 2.

Figure 2

Apoptosis of YAC128 MSNs is induced by synergistic actions of dopamine and glutamate. A, MSNs (14 DIV) from the WT and YAC128 mice were exposed to a range of dopamine (Dop.) concentrations (0 –500 μM) for 8 h, fixed, permeabilized, and analyzed by TUNEL staining (green) and propidium iodide counterstaining (red). B, The same experiment described in A was performed in the presence of 25 μM glutamate. C, D, The fraction of TUNEL-positive nuclei (shown in A and B) was determined and plotted against dopamine concentration for WT (open circles) and YAC128 (filled circles) MSNs. At each dopamine concentration, the data are shown as mean ±SD (n =4 – 6 microscopic fields, 200 –300 MSNs per field). Similar results have been obtained with six WT and YAC128 MSN cultures.