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. Author manuscript; available in PMC: 2013 Feb 7.
Published in final edited form as: Hepatology. 2012 Jun 11;56(2):658–667. doi: 10.1002/hep.25671

Figure 6. Induction of UGT1A1 by dexamethasone in neonatal hUGT1*1 and hUGT1/Pxr−/− mice.

Figure 6

Humanized UGT1*1 and hUGT1/Pxr−/− mice at 12 days after birth were treated by oral gavage with 8 mg/kg DEX. A). Serum bilirubin levels in untreated (Ctrl) and DEX treated mice were evaluated in 14 day old mice (*** p<0.001, n.s. no significant difference, t-test). B). After DEX treatment, fold induction of UGT1A1 gene expression in liver was determined by RT and Q-PCR analysis.