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. Author manuscript; available in PMC: 2014 Jan 14.
Published in final edited form as: Acta Pharmacol Sin. 2011 Oct 10;32(11):1327–1336. doi: 10.1038/aps.2011.106

Figure 5. Slit2 expression changes blood vessel permeability at sites of cell-cell adhesion.

Figure 5

a Permeability of C57 and Slit2 mouse brains. The data represent the mean results from seven mice; bars, SE. **, P <0.01.

b Measurement of the ICH area in brain longitudinal section slides from C57 and Slit2 mice. The data represent the mean results from six mice; bars, SE. **, P <0.01.

c and d Longitudinal section slides of mouse brains in which ICH was induced. The ICH area was bigger in Slit2 mice (d) than in C57 mice (c).

e and f Immunoflorescence of HUVECs with anti VE-cadherin antibody. Cell-cell adhesion was different in Slit2 stimulated HUVECs (f) compared with cells not stimulated with Slit2 (e).

g Slit2 increases the permeability of HUVECs in in vitro permeability assays. The Robo blocking antibody R5 could block this effect.