Table 2.
Numbers of mice examined from each genotype for each of the physiological and histological analyses performed in the present study
| M1 | M3 | M5 | M2 | M4 | M2/M4 | |
|---|---|---|---|---|---|---|
| Thresholds (ABR/DPOAE) | +/+=26 | +/+=29 | +/+=22 | +/+=16 | +/+=16 | +/+=10 |
| −/−=13 | −/−=13 | −/−=14 | −/−=8 | −/−=8 | −/−=11 | |
| Efferent function | +/+=4 | +/+=8 | +/+=4 | +/+=5 | ||
| −/−=5 | −/−=10 | −/−=3 | −/−=6 | |||
| Temporary noise damage | +/+=4 | +/+=6 | +/+=6 | +/+=6 | +/+=36 | +/+=7 |
| −/−=3 | −/−=3 | −/−=4 | −/−=4 | −/−=4 | −/−=7 | |
| Permanent noise damage | +/+=4 | +/+=8 | +/+=8 | +/+=8 | +/+=8 | +/+=7 |
| −/−=3 | −/−=5 | −/−=8 | −/−=8 | −/−=8 | −/−=7 | |
| Cochlear histopathology | +/+=3 | +/+=3 | +/+=3 | +/+=2 | ||
| −/−=5 | −/−=3 | −/−=3 | −/−=2 |
Histopathology and efferent function were not evaluated in the M2 or M4 single nulls, once we determined that the double nulls (M2/M4) were normal by both these assays.