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. Author manuscript; available in PMC: 2013 Nov 25.
Published in final edited form as: Cell Prolif. 2011 Jun 6;44(4):10.1111/j.1365-2184.2011.00757.x. doi: 10.1111/j.1365-2184.2011.00757.x

Figure 7. Signalling cascades modulated by CXCL13 in PCa cell lines.

Figure 7

CXCL13 signalling through its cognate receptor, CXCR5, elicits Akt and ERK1/2 activation. In LNCaP cells, CXCL13 also regulates JNK activation presumably via Gαq/11 coupled to CXCR5, which potentially mediates phospholipase C (PLC) and protein kinase C (PKC) activation. In PC3 cells, however, JNK activation is mediated through DOCK2, a differentially expressed protein that acts as a guanine nucleotide exchange factor to activate Rac isoforms and contributes to cell proliferation.