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. Author manuscript; available in PMC: 2012 Nov 2.
Published in final edited form as: J Neurosci. 2012 May 2;32(18):6081–6091. doi: 10.1523/JNEUROSCI.6519-11.2012

Figure 6. Co-application of low concentrations of CCH and DHPG induces a post-burst ADP.

Figure 6

(A) Individual responses to bursts of five action potentials in baseline condition (gray, t = 0 min in B) or after application (black, t = 15 min in B) of either CCH (3 μM), DHPG (0.75 μM), or both (3 μM CCH + 0.75 μM DHPG). (B) Timecourses of the post-burst potential amplitudes following application of either CCH, DHPG, or both. Gray-shaded area indicates period of drug application. (C) Summary of the Δ post-burst potentials (t = 15 min minus t = 0 min response) in each condition. In CCH groups; 3 μM, n = 12; 6 μM, n = 11. In DHPG groups; 0.75 μM, n = 15; 1.5 μM, n = 11. In CCH + DHPG group; 3 μM CCH + 0.75 μM DHPG; expt, n = 16. For the linear sum, 16 randomly selected pairs were used from the independent measures in 3 μM CCH and 0.75 μM DHPG. One-way ANOVA, p < 0.0001; post-hoc tests vs. expt, ** p < 0.001.