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A schema of the neuromuscular junction in wild type, sofa potato and twitch once backgrounds. Note that over-expression changes the distribution, and over-expressed proteins are not shown in this schema. Only AChR α subunits are shown in sofa potato, which mAb35 visualized. GE rapsyn designates rapsyn with G130E mutation. The distribution of AChR and rapsyn displayed distinct patterns, revealing the role of their interactions in the proper trafficking.
