Table 2.
Correlation† of lipoprotein-associated phospholipase A2 (Lp-PLA2) level (ng/mL) with coronary risk factor and nuclear magnetic resonance (NMR) lipoprotein subclasses among American and Japanese men
| Americans N=100 | Japanese N=93 | |
|---|---|---|
| Age (years) | 0.02 | -0.13 |
| Waist girth (cm) | -0.20* | -0.16 |
| Body mass index (Kg/m2) | -0.15 | -0.12 |
| Systolic blood pressure (mmHg) | 0.01 | -0.08 |
| Diastolic blood pressure (mmHg) | 0.01 | -0.12 |
| Total cholesterol (mg/dL) | 0.37*** | 0.30** |
| Triglycerides (mg/dL) b | 0.06 | -0.07 |
| HDL cholesterol (mg/dL) | -0.09 | 0.07 |
| LDL cholesterol (mg/dL) | 0.44*** | 0.30** |
| Fasting glucose (mg/dL) | 0.02 | -0.20 |
| Fasting insulin (μIU/mL) | -0.11 | -0.09 |
| C-reactive protein (mg/L) b | 0.11 | 0.04 |
| Fibrinogen(μmol/l) | -0.09 | 0.01 |
| Total VLDL Particles (nmol/L) | 0.27** | 0.02 |
| Large VLDL/Chylomicrons (nmol/L) | 0.01 | -0.07 |
| Medium VLDL (nmol/L) | 0.16 | -0.07 |
| Small VLDL (nmol/L) | 0.32** | 0.17 |
| Total LDL Particles (nmol/L) | 0.14 | 0.08 |
| IDL (nmol/L) | -0.07 | -0.01 |
| Large LDL (nmol/L) | 0.52** | 0.22* |
| Small LDL (total) (nmol/L) | -0.17 | -0.05 |
| Medium Small LDL (nmol/L) | -0.21* | -0.06 |
| Very Small LDL (nmol/L) | -0.16 | -0.05 |
| Total HDL Particles (nmol/L) | -0.10 | -0.01 |
| Large HDL (nmol/L) | 0.11 | 0.11 |
| Medium HDL (nmol/L) | -0.25* | -0.12 |
| Small HDL (nmol/L) | -0.10 | -0.06 |
| VLDL Size (nm) | -0.12 | -0.15 |
| LDL Size (nm) | 0.35** | 0.10 |
| HDL Size (nm) | 0.12 | 0.18 |
†
Pearson’s rho with normal data or Spearman’s rho with skewed data
*
<0.05
**
<0.01
***
<0.001
Abbreviations: LDL, low density lipoprotein; HDL, high density lipoprotein; IDL, intermediate density lipoprotein; VLDL, very low density lipoprotein.