Table 3.
Cytotoxicity (% lysis at E:T = 40:1) with effectors: |
|||||
---|---|---|---|---|---|
Targets | IFNγa | TIL 660 | TIL 1074 | TIL 1143 | LAK cells |
RD-ES | − | 6 | 0 | 0 | 75 |
+ | 25 | 0 | 25 | 48 | |
TC-71 | − | 1 | 9 | 0 | 48 |
+ | 10 | 26 | 31 | 58 | |
6647 | − | 3 | 2 | 2 | 65 |
+ | 0 | 3 | 38 | 26 | |
624-mel | − | 55 | 25 | 34 | 55 |
+ | 65 | 35 | 49 | 26 |
Results are from 4-h 51Cr-release assay. Lysis above 10% is considered significant. LAK, lymphokine-activated killer
IFNγ pretreatment of targets, 500 U/ml for 72 h