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. Author manuscript; available in PMC: 2012 Dec 20.
Published in final edited form as: J Neurosci. 2012 Jun 20;32(25):8532–8544. doi: 10.1523/JNEUROSCI.0337-12.2012

Figure 6. M1-selective agonists VU0364572 and VU0357017 induce small changes in action potential spiking frequency in medium spiny neurons.

Figure 6

(a.) The membrane potential response to a current step before and after application of CCh (10 μM) in medium spiny neurons of rats. CCh (n=7) induces a robust increase in evoked action potential firing. (b.) Response to current injection following application of VU0364572 (n=5). (c.) Response to current injection following application of VU0357017 (n=5). (d.) Bar graph showing the change in number of spikes/pulse following addition of test compounds.