Table 1.
Phenotypic outcomes of postulated pathways including APP and/or APLP2
| Pathway Type | APP & APLP2 Pathway Relationship | APP & APLP2 Role | Growth of cells expressing APP siRNA or APLP2 siRNA | Growth of cells expressing APP siRNA and APLP2 siRNA |
|---|---|---|---|---|
| Same | Same | Same | No effect | ↓ |
| Same | Same | Unique | ↓ | ↓ (to same extent as cells expressing either siRNA) |
| Same | Sequential | Unique | ↓ | ↓ (to same extent as cells expressing either siRNA) |
| Same | Parallel | Unique | No effect | ↓ |
| Parallel | + & + | Unique | ↓ | ↓ |
| Parallel | + & inhibits inhibitor | Unique | ↓ | ↓ |
| Parallel | Inhibits inhibitor & inhibits inhibitor | Unique | ↓ | ↓ |
| Unrelated | Separate | Unique | ↓ | ↓ |
Key: ↓ denotes reduced cell growth
+ signifies positively regulates cell growth