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. Author manuscript; available in PMC: 2013 Jan 4.
Published in final edited form as: J Neurosci. 2012 Jul 4;32(27):9410–9418. doi: 10.1523/JNEUROSCI.1041-12.2012

Figure 3.

Figure 3

The effects of intraperitoneal (IP; A) or oral (B) administration of saline or methylphenidate (MPH) on locomotor activity in 42-day old male mice in the prenatal saccharin only exposure (SAC) and nicotine+saccharin exposure (PNE) groups. Locomotor activity was recorded for 4 hr. Mice in the PNE group showed significantly increased activity compared to their counterparts in the SAC group when saline was administered to both the groups either intraperitoneally (A) or orally (B). Intraperitoneal MPH did not produce significant changes in the locomotor activity in PNE group at any of the 5 doses (A). However, it increased locomotor activity in the SAC group at 3.75 and 7.5 mg/kg doses (A). Oral MPH administration did not affect locomotor activity in the SAC group at either dose (B). However, 0.75 mg/kg MPH significantly decreased locomotor activity in the PNE group. ANOVA and multiple comparison tests were used to test statistical significance of the experimental effects (n=6 for each group).