Table 1.

Mean±SEM values (fMol/mg protein) of tissue concentrations of dopamine (DA), DOPAC, serotonin (5-HT), 5-HIAA and the turnover rates (DOPAC/DA and 5-HIAA/5-HT) in the prenatally saccharin exposed (SAC) or nicotine exposed (PNE) mice. A. Baseline tissue concentrations in the frontal cortex and the striatum (n=16 for each SAC or PNE). B. Tissue concentrations in the frontal cortex 1 hr after oral gavage of saline (Sal, n=15) or 0.75 mg/kg methylphenidate (MPH, n=13).

			DA	DOPAC	DOPAC / DA	5-HT	5-HIAA	5-HIAA / 5-HT
A
	Frontal cortex	SAC	57.9 ± 19.01	127.58 ± 36.13	2.29 ± 0.38	361.35 ± 61.57	168.54 ± 46.14	0.35 ± 0.07
		PNE	187.7 ± 38.8 **	148.96 ± 25.85	1.09 ± 0.3 *	387.83 ± 46.69	289.66 ± 77.52	0.62 ± 0.14
	Striatum	SAC	2559.31 ± 611.92	254.56 ± 69.34	0.11 ± 0.02	313.86 ± 62.19	188.63 ± 63.86	0.48 ± 0.13
		PNE	3388.86 ± 618.03	258.34 ± 57.68	0.06 ± 0.01 *	386.78 ± 44.16	236.37 ± 45.75	0.57 ± 0.1
B
	PNE	SAL	197.31 ± 40.24	144.05 ± 27.13	0.83 ± 0.15	391.55 ± 50.98	295.05 ± 84.71	0.62 ± 0.15
	PNE	MPH	160.91 ± 62.76	230.04 ± 83.25	1.75 ± 0.29 **	296.31 ± 60.19	181.92 ± 74.78	0.45 ± 0.12

^**p<0.01,

^*p<0.05.