Table 2.
Clinical signs in vaccinated ferrets after lethal challenge with VN1203 (H5N1) virus
| Maximum % weight loss within 10 days of inoculationa |
Maximum temperature increase (°C) 1 day after inoculationa,b |
|||
|---|---|---|---|---|
| Vaccine | Challenge after first vaccination | Challenge after first vaccination | ||
| 5 months | 1 year | 5 months | 1 year | |
| VN1203 | 4.3 | 5.4c | 0.1 | 1.4 |
| DKHUN795 | 4.6 | 6.5 | 0.0 | 1.4 |
| A | 4.3 | 4.0 | 0.6 | 1.4 |
| D | 0.0 | 2.1 | 0.3 | 1.0 |
| PBSd | 23.0 | 16.0 | 1.2 | 1.7 |
a
Mean maximum weight loss or temperature increase per group (n=2 per group).
b
Highest temperature was observed 1 day post-inoculation in all groups.
c
N = 1 in this group only.
d
All PBS-vaccinated animals died or were euthanized by day 5 post-inoculation.