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. Author manuscript; available in PMC: 2009 Jun 8.
Published in final edited form as: Bioorg Med Chem Lett. 2007 Oct 30;18(1):220–222. doi: 10.1016/j.bmcl.2007.10.095

Scheme 2.

Scheme 2

Reactions and conditions. a, NaH, PMBCl, DMF, 0 °C, 81%; b, NaIO4, OsO4, MeOH/H2O, then NaBH4, MeOH, 53%; c, DAST, pyridine, CH2Cl2, 76%; d, DDQ, CH2Cl2/H2O, 60%; e, DIAD, TPP, Ad(Boc)2; f, 3N HCl/MeOH, 58% for two steps.