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. Author manuscript; available in PMC: 2013 Feb 8.
Published in final edited form as: J Neurosci. 2012 Aug 8;32(32):11067–11081. doi: 10.1523/JNEUROSCI.5604-11.2012

Figure 2. Frequency, amplitude and kinetics of spontaneous EPSCs are altered in stg RTN cells.

Figure 2

Representative traces from wt (A and D) and stg (B and E) RTN cells of continuous voltage-clamp recordings of RTN cells held at resting membrane potential (Vh = −60 mV) under conditions that isolate ionotropic sEPSCs (A–C) and AMPAR sEPSCs (D–F).. Ci Ensemble averaged sEPSCs from representative cells shown in A (black; wt) and B (grey; stg) superimposed on the same time-scale. Cii Averaged sEPSC from Ci normalized and aligned to peak to illustrate the slower kinetics of stg sEPSCs. Di Ensemble averaged sEPSCs from representative cells shown in D (black; wt) and E (grey; stg) superimposed on the same time-scale. Dii Averaged sEPSC from Di normalized and aligned to peak to illustrate the slower kinetics of stg AMPAR-sEPSCs. Remaining events were blocked by NBQX or DNQX 20 μM confirming that the latter were AMPA receptor mediated events (data not shown).