Serum Cyr61 levels measured by sandwich ELISA. (a) Cyr61 concentrations in serum samples obtained from OC-PCa (n=58) and NOC-PCa (n=57) patients, demonstrating significant difference (*P=0.031). (b) Cyr61 concentrations in serum samples obtained from PCa patients without PSA recurrence (Non-Rec, n=10) and those with PSA recurrence (Rec, n=10), demonstrating no significant difference (P=0.082). This figure is reproduced from D’Antonio et al.19 Cyr61, cysteine-rich angiogenic inducer 61; NOC, non-organ-confined; OC, organ-confined; PCa, prostate cancer.