Skip to main content
. Author manuscript; available in PMC: 2013 Mar 5.
Published in final edited form as: J Neurosci. 2012 Sep 5;32(36):12337–12348. doi: 10.1523/JNEUROSCI.2129-12.2012

Fig. 3. The α7 nAChR-mediated LTP involves prolonged calcium activity enhancement in both pre- and postsynaptic sites in septo-hippocampal slice co-cultures.

Fig. 3

LTP was induced by pairing SO pathway 100 ms before SC pathway in septo-hippocampal slice co-cultures. (A) Normalized SC pathway stimulation-induced postsynaptic GCaMP3 responses showing the prolonged enhancement of postsynaptic calcium activities after the SO pathway pairing protocol. SC pathway was stimulated at the time point of 0 sec. (B) Images of SC pathway-induced postsynaptic calcium imaging from different time points before or after pairing protocol. (C) Normalized presynaptic GCaMP3 responses showing the prolonged enhancement after the SO pathway pairing protocol. (D) Images of presynaptic calcium imaging from different time points before or after pairing protocol. (E) Bar graph showing the prolonged post- and presynaptic responses during LTP; both were abolished in α7 nAChR knockout slices. *p<0.01, **p<0.001, as compared with before pairing, Student t-test, n=6 in each group.