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. Author manuscript; available in PMC: 2013 Mar 5.
Published in final edited form as: J Neurosci. 2012 Sep 5;32(36):12337–12348. doi: 10.1523/JNEUROSCI.2129-12.2012

Fig. 5. The α7 nAChR-mediated STD involves transient calcium activity depression in both post- and presynaptic sites.

Fig. 5

The α7 nAChR-dependent STD was induced by pairing SO 10 ms before SC. (A) Normalized postsynaptic GCaMP3 responses showing the transient depression of postsynaptic calcium activities after the SO pathway pairing protocol. (B) Images of postsynaptic calcium imaging from different time points before or after pairing protocol, with individual panels similar as described in Fig. 4B. (C) Normalized presynaptic GCaMP3 responses showing the transient depression after the SO pathway pairing protocol. (D) Images of presynaptic calcium imaging from different time points before or after pairing protocol. (E and F) Bar graphs showing that the presence of α7 nAChRs at both pre- and postsynaptic sites was required to induce the STD. Red signals (in B and D) show the SC stimulation-induced calcium increases (also shown separately in the middle panels) over the basal signals before stimulation (green). Arrows indicate some synaptic sites with significant transient calcium decrease. *p<0.01, **p<0.001, as compared with before pairing, Student t-test, n=5 in each group.