Table 3.

Phenotypes of Eya mutant mice

Mouse mutant	Phenotype	References
Eya1−/−	Die at birth with craniofacial and skeletal defects, ear malformation, dysmorphic/absent kidneys, thymus and parathyroid agenesis, thyroid hypoplasia, open eyelids. Hypoplastic lungs.	[59,156,60]
Eya2−/−	No external phenotype, viable and fertile.	[157]
Eya1−/− Eya2−/+	No diaphgram, severe limb muscle hypoplasia.	[157]
Eya3−/−	Viable and fertile with no external phenotype. Reduced body length.	[108]
Eya4−/−	Die shortly after birth. Abnormal ear development and hearing deficiency. Males were sterile or had reduced fertility.	[105]