Table 2.

Correlations between Fos expression in VTAafferentsand behavior

		Lever presses/% Fos + CTb cells		Beam breaks/% Fos + CTb cells
Structure/Macrosystem	Subregion	All cocaine seeking	CS + Reinst. only	Horizontal locomotion	Vertical locomotion
Extended amygdala	AA	0.63**	0.07	−0.37	0.22
	DBNST	0.46*	−0.11	0.57	0.65
	VBNST	0.74**	0.58	0.60	0.65
	IPAC	−0.03	−0.28	0.03	0.45
	MeA	0.29	0.48	0.01	0.83*
	CeA	0.44	0.37	0.61	−0.58
	SLEA	0.36	−0.57	0.45	0.73
	Stia	0.43	0.53	0.01	0.01
Accumbens core	Core	0.51*	−0.08	0.19	−0.18
Accumbens shell	Rostral Pole	0.08	−0.44	0.01	0.29
	DM-Rostral	0.28	−0.50	0.44	0.29
	VM-Rostral	0.20	0.18	0.58	−0.79
	DM-Caudal	0.42	−0.41	0.40	0.30
	VM-Caudal	0.88***	0.80*	0.63	0.41
	Lateral	0.77***	0.43	0.04	−0.77
Pallidum	VP	0.63**	0.91	0.58	0.54
Septum	LS	0.57**	−0.22	0.42	0.68
	MS	0.55**	0.41	0.31	0.87*
Cortex-like amygdala	BLA	−0.25	−0.95**	−0.18	0.69
	BMA	0.30	−0.10	−0.59	0.19
Prefrontal cortex	CG1	−0.11	−0.74*	0.56	0.27
	CG2	−0.23	−0.09	0.20	−0.48
	PLC	0.26	0.42	0.05	0.27
	ILC	−0.25	−0.42	0.64	0.05
	DP	0.45	0.43	0.46	0.30
	DTT	0.40	0.01	0.30	0.06
	NavN	0.44	0.18	0.25	−0.26
	MOFC	0.11	−0.19	−0.35	0.90*
	DLOFC	−0.19	−0.15	0.98**	0.35
	LOFC	0.27	0.14	−0.32	0.10
	VOFC	0.34	0.26	−0.60	0.34
	DEn	0.45	0.05	0.78	0.11
	Claust	−0.16	−0.78*	0.71	0.36
Hypothalamus	AH	0.10	−0.69	−0.69	0.46
	PH	0.28	0.32	−0.41	0.23
	LH	0.74***	0.06	0.11	0.49
	VMLH	0.39	0.38	−0.40	0.91*
	DMH	0.38	0.59	−0.16	0.90*
	VMH	0.46	0.57	0.51	−0.08
	PFA	0.49*	−0.14	−0.40	0.59
	LPO	0.38	−0.34	0.32	0.48
	MP0	0.47	0.00	0.00	0.65
	PVH	0.32	−0.72	0.38	0.54
	pmamm	0.18	0.52	0.16	0.94*
Habenula	MHb	−0.36	−0.71	0.53	−0.56
	LHb	−0.44	0.03	0.76	0.13
Raphe nucleus	Dorsal	−0.12	−0.19	−0.05	0.21
	Medial	−0.28	0.32	−0.37	−0.72
	Para medial	−0.01	0.10	−0.16	−0.16
Tegmentum	PPT-Rostral	0.07	−0.11	0.51	−0.29
	PPT-Caudal	0.20	−0.42	0.39	0.54
	RMTg/tVTA	−0.48*	0.16	0.71	−0.45
	SC	−0.20	−0.12	0.12	0.10

Correlations of Fos in VTA afferent neurons with cocaine-seeking behavior, cued reinstatement behavior horizontal locomotion, and vertical locomotion are shown. “All cocaine seeking” behavior is defined as active lever presses in the first 30 min of CS + reinstatement, CS− control, and extinction control sessions (n = 19). “CS + Reinstatement Only” (Reinst. Only) behavior is defined as cue-triggered reinstatementwi thin the CS + reinstatement group alone(n = 8). Horiiontal and vertical locomotion was measured in the locomotor control group (n = 6). Significant correlationsare designated as

^*p<0.05,

^**p<0.01,

^***p<0.001.