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. Author manuscript; available in PMC: 2013 Mar 19.
Published in final edited form as: J Neurosci. 2012 Sep 19;32(38):13155–13163. doi: 10.1523/JNEUROSCI.2530-12.2012

Figure 4. METH and brain ammonia.

Figure 4

Rats were treated with METH (10 mg/kg × 4 i.p every 2 hrs) or saline (1 mL/kg ×4 i.p. every 2 hrs) and lactulose (5.3 g/kg p.o. every 12 hrs) or vehicle (8 mL/kg, every 12 hrs). During drug treatment (arrows denote injections), striatal ammonia concentration was measured using in-vivo microdialysis. Vehicle+METH treatment significantly increases brain ammonia concentrations starting at timepoint 5 and Lactulose pretreatment attenuates this increase (*=p<0.05). Baseline=29.34±5.33 µM. (n=8–10 rats per group) Veh=Vehicle, Lac=Lactulose, Sal=Saline