Skip to main content
. Author manuscript; available in PMC: 2013 Mar 19.
Published in final edited form as: J Neurosci. 2012 Sep 19;32(38):13155–13163. doi: 10.1523/JNEUROSCI.2530-12.2012

Figure 8. Effects of local administration of ammonia, METH, and GYKI 52466 into the striatum.

Figure 8

Rats were reverse dialyzed with METH(100 µM), Ammonia (570 µM), and/or GKYI 52466 (100 µM) in the striatum for 8 hrs and dopamine and 5HT tissue content of the striatal tissue around the probe membrane (1 mm) was measured 7 days later. A) Treatment with the combination of METH and ammonia depletes dopamine in the tissue around the probe by 51.5±12.5% (Mean±SEM). B) Treatment with the combination of METH and Ammonia depletes 5-HT in the tissue around the probe by 41.8±7.0% (Mean±SEM) compared to aCSF. C) Treatment with GYKI 52466 significantly attenuates depletions in dopamine tissue content produced by METH and ammonia D) Treatment with GKYI 52466 significantly attenuates depletions in 5HT tissue content produced by the combination of METH and ammonia. (* p<0.05 compared to aCSF, & p<0.05 compared to Ammonia METH) (n=10 rats per group) aCSF=artificial cerebrospinal fluid, GYKI=GYKI 52466