Q1	Depressed mood
	Depressed mood most of the day, nearly every day, as indicated by either subjective report (e.g., feels sad or empty) or observations made by others.
Q2	Loss of interest (anhendonia)
	Markedly diminished interest or pleasure in all, or almost all, activities most of the day, nearly every day (as indicated by either subjective account or observation made by others).
Q3	Weight or appetite changes
	Significant weight loss when not dieting or weight gain (e.g., change of more than 5% of body weight in a month), or decrease or increase in appetite nearly every day.
Q4	Sleep problems
	Insomnia or hypersomnia nearly every day (sleep disturbance of any type).
Q5	Objective psychomotor activities
	Psychomotor agitation or retardation nearly every day (observable by others, not merely subjective feelings of restlessness or being slowed down).
Q6	Fatigability
	Fatigability or loss of energy nearly every day.
Q7	Worthlessness
	Feelings of worthlessness or excessive or inappropriate guilt (which may be delusional) nearly every day (not merely self-reproach or guilt about being sick).
Q8	Concentration difficulty
	Diminished ability to think or concentrate, or indecisiveness, nearly every day (either by subjective account or as observed by others). Complaints or evidence of diminished ability to think or concentrate, such as indecisiveness or vacillation.
Q9	Suicidal ideation
	Recurrent thoughts of death (not just fear of dying), recurrent suicidal ideation without a specific plan, or a suicide attempt or a specific plan for committing suicide.
Q10	Loss of confidence
	Loss of confidence or self-esteem.
Q11	Self-reproach
	Unreasonable feelings of self-reproach or excessive and inappropriate guilt.
Q12	Psychomotor symptom (objective or subjective)
	Change in psychomotor activity, with agitation or retardation either objectively observed by others or subjectively-assessed
Q13	Weight and appetite changes
	Change in appetite (decrease or increase) with corresponding weight change.
Q14	Nonreactive depressed mood
	Depressed mood to a degree that is definitely abnormal for the individual, present for most of the day and almost every day, largely uninfluenced by circumstances, and sustained for at least two weeks.