Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Cellular Assay and ITC data for select SBiX compounds
| Compound | Structure | Cell Assay (High S100B) | Cell Assay (Low S100B) | KD by 1D NMR |
|---|---|---|---|---|
| 1 (Pentamidine) |
|
10.2 ± 4.0 μM | 12.2 ± 4.7 μM | 0.13 ± 0.04 μM1 |
| 4210 (Hexamidine) |
|
NB | NB | NB |
| 4211 (Heptamidine) |
|
4.2 ± 2.0 μM | 6.8 ± 1.9 μM | 6.9 ± 0.9 μM |
NB: No Binding; 1KD listed is for the tight site, binding to the weaker site (KD = 40 ± 5 μM) is described in detail elsewhere14.
