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. Author manuscript; available in PMC: 2013 Apr 10.
Published in final edited form as: J Neurosci. 2012 Oct 10;32(41):14087–14093. doi: 10.1523/JNEUROSCI.3242-12.2012

Table 1.

Nf1 Genetically-Engineered Mouse Models of CNS Dysfunction

GEM Strain Description CNS Abnormality Reference
Nf1+/− mice mice with reduced Nf1
gene expression
throughout		 impaired learning,
memory, and
attention; increased
astrogliosis		 Jacks et al., 1994;
Silva et al., 1997;
Gutmann et al., 1999;
Rizvi et al., 1999
Nf1+/−Syn mice mice with reduced Nf1
gene expression in
hippocampal neurons		 impaired learning,
memory, and
attention		 Cui et al., 2008
Nf1+/−GFAPCKO mice Nf1+/− mice with
complete Nf1 loss in
neuroglial progenitors		 impaired learning,
memory, and
attention; optic glioma
formation		 Brown et al., 2010a;
Bajenaru et al., 2003
Nf1+/−; KRasGFAP mice Nf1+/− mice with
KRas activation in
neuroglial progenitors		 optic glioma formation Dasgupta et al., 2005a
Nf1;p53GFAPCKO mice mice with Nf1 and p53
inactivation in
neuroglial progenitors		 high-grade glioma
formation		 Zhu et al., 2005b
Nf1;p53;
PtenGFAPCKO mice		 mice with Nf1,p53,
and Pten inactivation
in neuroglial
progenitors		 GBM formation Kwon et al., 2008
Nf1;p53;
PtennestinCKO mice		 mice with Nf1,p53,
and Pten inactivation
in neural stem cells		 GBM formation Chen et al., 2012