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. Author manuscript; available in PMC: 2013 May 7.
Published in final edited form as: J Neurosci. 2012 Nov 7;32(45):16018–16030. doi: 10.1523/JNEUROSCI.1685-12.2012

Figure 7. Dnlg2 expression is required in pre- and post-synaptic areas for rescue of synaptic transmission defects in dnlg2 mutants.

Figure 7

(A–C) Quantification of electrophysiological analyses for dnlg2 and dnrx273 single and dnlg2;dnrx double mutants at muscle 6 of the third abdominal segment. dnlg2 and dnrx273 single and dnlg2;dnrx double mutants showed reduced EJP amplitudes (A) but normal mEJP amplitude (B). All the mutants have reduced quantal contents (C). Similarly, pre-(elav-Gal4) and post-synaptic (24B- or C57-Gal4) expression of Dnlg2 in dnlg2CL2 and dnlg2KO70 mutants failed to restore EJP amplitudes (A) and quantal content (C) deficits. Ubiquitous expression of Dnlg2 using tubP-Gal4 in both dnlg2CL2 and dnlg2KO70 mutants restores the EJP amplitude (A) to control levels. mEJP amplitudes (B) remain unchanged in dnlg2CL2 mutants when Dnlg2 is expressed pre- and post-synaptically alone or in combination. However, an increase in mEJP amplitude is seen when Dnlg2 is expressed in muscles using C57-Gal4 in dnlg2KO70 mutants while no changes were observed when Dnlg2 is expressed using elav- or tubP-Gal4. ***p < 0.001; **p < 0.01; *p < 0.05 (Student’s t test).