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. Author manuscript; available in PMC: 2013 Apr 29.
Published in final edited form as: Brain Struct Funct. 2012 May 23;218(3):767–778. doi: 10.1007/s00429-012-0427-0

Fig. 3.

Fig. 3

Comparison of DTI parameters in regions of interest. Column graphs showing average bilateral fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) values in a priori segmented regions of interest. A significantly increased average FA value was seen in the ventral striatum, globus pallidus, entopeduncular nucleus, and substantia nigra of transgenic HD rats (*p<0.05; **p <0.0125, significance level after Bonferroni's correction). The increased average FA value in the dorsal striatum was close to significance ((*)p <0.1). No FA differences were seen in the other regions investigated. Significantly reduced MD and AD values were found in the globus pallidus (**p <0.0125) and entopeduncular nucleus (*p < 0.05) of the transgenic HD rats, while significantly reduced RD was observed in the entopeduncular nucleus (**p < 0.0.125). A RD reduction close to significance was also seen in the substantia nigra ((*)p<0.1). Similar trends of reduced diffusivity were also observed in the striatum, substantia nigra, and internal capsule, however not reaching significance. No MD, AD, or RD differences were seen in the other regions investigated. cc Corpus callosum, CPu caudate–putamen complex (dorsal striatum), CPu/Acb caudate–putamen complex and accumbens nucleus (ventral striatum), EP entopeduncular nucleus, GP globus pallidus, ic internal capsule, lfp longitudinal fibers of the pons, PN pontine nuclei, SC superior colliculus, SN substantia nigra, HD transgenic HD rats, WT wild-type rats