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. Author manuscript; available in PMC: 2013 Feb 7.
Published in final edited form as: J Immunol. 2012 Dec 26;190(3):1048–1055. doi: 10.4049/jimmunol.1202455

Figure 6. Selective depletion of IM has no effect on the PPS14- or PC-specific IgG responses to soluble pneumococcal conjugate vaccines (PPS14-PspA + CPS-PspA).

Figure 6

CD11b-DTR BM chimeric mice (7 mice/group) with or without injection of DT 24 h earlier, were injected i.p. with PPS14-PspA (1 µg/mouse) in alum + CpG-ODN. DT was administered every 2–3 d for the duration of the experiment. Mice were boosted with PPS14-PspA on d 14 in a similar manner. Serum titers of antigen-specific IgM and IgG were measured by ELISA. *Significance p≤0.05. One of two representative experiments.