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The rapid down-regulation of CYP2B proteins elicited by IL-1 requires the induction of NOS2, and subsequent NO production. We hypothesized previously that NO modifies CYP2B protein (CYP2B*) and tags it for ubiquitination and for proteasomal degradation [26]. IL-1 acts via NO-independent mechanisms to accelerate this degradation, including the induction of the immunoproteasome.
