Skip to main content
. Author manuscript; available in PMC: 2013 Jul 15.
Published in final edited form as: J Neurosci. 2013 Jan 9;33(2):495–506a. doi: 10.1523/JNEUROSCI.3710-12.2013

Figure 5. Intra-vmPFC pretreatment with mGluR-targeting compounds produces residual effects upon cue-reinforced responding in cocaine-experienced animals.

Figure 5

(A) When tested for cue-reinforced behavior 24 h following an intra-vmPFC infusion of 3.0 μg/side MTEP prior to initial testing for cue-reinfoced behavior (MTEP PreRx) or an intra-vmPFC infusion of 30 pg/side of JNJ16259685 either prior to (JNJ PreRx) or immediately following (JNJ Post-Rx) the initial test for cue-reinforced behavior in the absence of any further intracranial manipulation, vehicle (VEH)-pretreated rats exhibited reduced responding (extinction), while no behavioral extinction was apparent in animals pre- or post-treated with mGluR antagonists (B) In contrast to the vmPFC, intra-dmPFC pretreatment with 30 pg/side JNJ16259685 failed to influence behavioral extinction at 3 days withdrawal. (C) Interestingly, when assayed at 30 days withdrawal, VEH-pretreated rats exhibited no sign of behavioral extinction when tested for cue-reinforced behavior, while extinction was facilitated in cocaine-experienced animals pretreated with 27 ng/side of DHPG. Sample sizes are indicated in parentheses. *p<0.05 vs. Test 1. +main effect of Test, p<0.05.