Table 2.

Altered metabolites in spinal cord of chronically-injured rats treated with licofelone. Bolded p values ≤ 0.05 (16 metabolites) and non-bolded p values ≤ 0.10 (10 metabolites) versus chronic SCI, vehicle-treated group. Welch’s two-sample t test.

Class	Sub-class	Biochemical Name	HMDB ID	Fold Change (SCI + licofel one / SCI + vehicle)	p Value	q Value
Amino acid	Alanine and aspartate metabolism	aspartate	HMDB00191	1.10	0.0471	0.6549
Carbohydrate	Aminosugars metabolism	erythronate	HMDB00613	1.18	0.0287	0.7033
		N-acetylneuraminate	HMDB00230	1.22	0.0421	0.3346
	Fructose, mannose, galactose, starch, and sucrose metabolism	maltose	HMDB00163	1.28	0.0417	0.5323
	Glycolysis, gluconeogenesis, pyruvate metabolism	glucose	HMDB00122	1.27	0.0633	0.6236
		lactate	HMDB00190	1.11	0.0223	0.7266
	Nucleotide sugars, pentose metabolism	arabitol ribose	HMDB01851	1.59	0.0030	0.6236
			HMDB00283	1.47	0.0836	0.7033
Energy	Krebs cycle	citrate	HMDB00094	1.16	0.0877	0.4537
Lipid	Long chain fatty acid	margarate (17:0)	HMDB02259	1.22	0.0077	0.3346
		cis-vaccenate (18:1n7)	-	1.26	0.0183	0.7266
		behenate (22:0)	HMDB00944	1.20	0.0615	0.7266
	Eicosanoid	15-hydroxyeicosatetraenoic acid	HMDB02110	1.42	0.0328	0.3346
	Bile acid metabolism	taurocholate	HMDB00036	−2.44	0.0625	0.4537
	Glycerolipid metabolism	glycerol	HMDB00131	1.13	0.0090	0.7033
	Inositol metabolism	myo-inositol	HMDB00211	1.20	0.0704	0.7266
		chiro-inositol	-	1.51	0.0224	0.5614
		inositol 1-phosphate	HMDB00213	1.22	0.0163	0.7033
	Sterol/Steroid	cholesterol	HMDB00067	1.06	0.0081	0.3346
		7-alpha-hydroxycholesterol	HMDB01496	1.26	0.0209	0.7164
		7-beta-hydroxycholesterol	HMDB06119	1.19	0.0930	0.4537
		24(S)-hydroxycholesterol	HMDB01419	1.25	0.0013	0.4537
Nucleotide	Purine metabolism, urate metabolism	allantoin	HMDB00462	1.20	0.0709	0.7266
Peptide	Dipeptide	glycylglycine	HMDB11733	1.24	0.0625	0.3346
	Dipeptide derivative	homocarnosine	HMDB00745	1.14	0.0071	0.4537
Xenobiotics	Sugar, sugar substitute, starch	erythritol	HMDB02994	1.30	0.0755	0.7266