Figure 3.

CIMT in 1 year-old wild type and treated versus knockout and treated mice. Using 40× magnification and Image-Pro Plus software, measurements of intima to media were taken after calibration and averaged for each panel. The averages, with standard deviation, of the 5 untreated knockout mice (blue), 6 treated knockout mice (green), 5 untreated wild type mice (red), and 8 treated wild type mice (purple) were calculated. The difference between untreated wild type and knockout CIMT is statistically significant, p-value = 0.009*. There is a statistically significant difference between the untreated versus treated knockout groups (p=0.02)** but not between the untreated versus treated wild type.