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. Author manuscript; available in PMC: 2013 Jul 23.
Published in final edited form as: J Neurosci. 2013 Jan 23;33(4):1651–1659. doi: 10.1523/JNEUROSCI.3191-12.2013

Figure 2.

Figure 2

Tau reduction significantly decreases seizure frequency in Kcna1−/− mice. (A) Representative spontaneous cortical seizure recorded bilaterally in a Kcna1−/− mouse during chronic in vivo EEG monitoring. (B) Analysis of seizures/hour in double-mutant mice recorded for 9 or more hours. Both tau reduction and loss significantly decreased seizure frequency in Kcna1−/−Tau+/− (n=8) and Kcna1−/−Tau−/− (n=8) double mutants compared to Kcna1−/−Tau+/+ (n=8). Seizures were observed in 5/8 Kcna1−/−Tau+/+ mice, 0/8 Kcna1−/−Tau+/− mice, and only 1/8 Kcna1−/−Tau−/− mice. Total deletion of tau reduced the average seizure frequency by over 94%. * p<0.05; Kruskal-Wallis; error bars represent SEM.