Table 1.
Biomechanical and biochemical properties of GAG depleted TMJ disc samples. Data is presented as mean ± SD.
| TMJ Disc |
Hyaline Cartilage |
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|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PB | AB | IZM | IZC | IZL | AC | ||||||||
| Instantaneous | Control | 1.49 ± 0.47 | 0.93 ± 0.38 | 0.39 ± 0.10 | 0.36 ± 0.16 | 0.27 ± 0.13 | 4.31 ± 0.62 | ||||||
| Modulus (MPa) | C-ABC | 1.48 ± 0.38 | 0.86 ± 0.56 | 0.38 ± 0.19 | 0.37 ± 0.09 | 0.27 ± 0.15 | 3.72 ± 0.16 | ||||||
|
| |||||||||||||
| Relaxation | Control | 30.0 ± 4.4 | 22.7 ± 2.2 | 25.0 ± 2.5 | 23.6 ± 3.8 | 24.1 ± 1.5 | ⎤ * ⎦ |
591 ± 56 | ⎤ * ⎦ |
||||
| Modulus (kPa) | C-ABC | 29.4 ± 3.5 | 22.3 ± 2.4 | 21.8 ± 2.9 | 22.1 ± 1.7 | 21.1 ± 1.6 | 295 ± 67 | ||||||
|
| |||||||||||||
| Coefficient of | Control | 4.84 ± 1.71 | 3.08 ± 0.66 | 2.42 ± 0.44 | ⎤ * ⎦ |
2.52 ± 0.53 | ⎤ * ⎦ |
2.69 ± 0.56 | ⎤ * ⎦ |
10.71 ± 2.36 | ⎤ * ⎦ |
||
| Viscosity (MPa s) | C-ABC | 4.72 ± 1.38 | 3.01 ± 0.83 | 1.70 ± 0.28 | 1.69 ± 0.41 | 1.80 ± 0.44 | 4.99 ± 1.39 | ||||||
|
| |||||||||||||
| sGAG / Dry | Control | 0.494 ± 0.121 | ⎤ * ⎦ |
0.692 ± 0.070 | ⎤ * ⎦ |
0.880 ± 0.151 | ⎤ * ⎦ |
0.758 ± 0.177 | ⎤ * ⎦ |
0.927 ± 0.249 | ⎤ * ⎦ |
19.2 ± 2.1 | ⎤ * ⎦ |
| Weight (%) | C-ABC | 0.016 ± 0.011 | 0.014 ± 0.012 | 0.035 ± 0.008 | 0.020 ± 0.010 | 0.032 ± 0.008 | 10.5 ± 1.7 | ||||||
|
| |||||||||||||
| Collagen / Dry | Control | 88.3 ± 3.8 | 85.9 ± 5.9 | 81.5 ± 5.3 | 85.0 ± 4.8 | 78.4 ± 4.3 | 70.4 ± 3.3 | ⎤ * ⎦ |
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| Weight (%) | C-ABC | 87.6 ± 3.3 | 85.1 ± 5.1 | 81.6 ± 5.1 | 84.0 ± 3.5 | 80.6 ± 4.9 | 60.9 ± 3.7 | ||||||
|
| |||||||||||||
| Water | Control | 68.7 ± 2.8 | 71.0 ± 2.4 | 69.6 ± 2.0 | 70.4 ± 2.4 | 71.7 ± 3.2 | 79.9 ± 1.2 | ⎤ * ⎦ |
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| Content (%) | C-ABC | 67.1 ± 3.0 | 70.4 ± 2.3 | 69.1 ± 1.8 | 70.0 ± 1.9 | 70.1 ± 1.4 | 75.8 ± 0.9 | ||||||
*
indicates a statically significant difference between C-ABC treated and control samples for a given region (analyzed using a t-test with α = 0.05).