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. Author manuscript; available in PMC: 2013 Feb 22.
Published in final edited form as: Ther Hypothermia Temp Manag. 2011 Dec 20;1(4):185–192. doi: 10.1089/ther.2011.0012

Fig.1. SCHEMATIC ILLUSTRATING THE MECHANISMS OF ISCHEMIC / REPERFUSIONAL (I/R) INJURY AND THE EFFECTS OF THERAPEUTIC HYPOTHERMIA.

Fig.1

We illustrate the schema of mechanisms of ischemic/reperfusional (I/R) brain injury and the effective point of hypothermia treatment. The pathology of I/R injury is approximately separated as two mechanisms, i.e., the cell death following cellular dysfunction in ischemic phase, and the free radical production in reperfusion phase. The boxed arrow with entered “Hypothermia” means the estimated effective points in I/R cascade.