Figure 2. NRTN overexpression increases the density of PGP9.5-positive, but not CGRP-positive, nerve endings in the epidermis of footpad skin.
Immunolabeling of glabrous skin from WT (n=4; A, C) and NRTN-OE (n=4; B, D) mice. The number and intensity of PGP9.5-positive fibers is increased in NRTN-OE (B) relative to WT (A) skin. No change was evident for CGRP-positive fibers between NRTN-OE (D) and WT (C). Calibration bar=25 μm.