Table 4.
Change in gene expression in lumbar DRG and TG of NRTN-OE mice. ASIC2a, GFRα2, P2X3,Ret, Runx1 and TRPM8 were increased in ganglia of NRTN-OE mice relative to WT mice.
Gene Assayed | Percentage Change (DRG) | Percentage Change (TG) |
---|---|---|
ASIC2a | +95%* | +125%* |
ASIC2b | +20% | +13% |
GFRα1 | +6.0% | −17% |
GFRα2 | +62%* | +98%* |
GFRα3 | −32%* | −28%* |
Nav 1.8 | +13% | nd |
P2X3 | +84%* | +42%* |
p75 | −5.0% | −11% |
Piezo 2 | +15% | nd |
Ret | +77%* | +144%* |
Runx1 | +38%* | +76%* |
TrkA | −23% | −13% |
TRPA1 | +74* | +42* |
TRPM8 | +44%* | +84%* |
TRPV1 | −22% | −10% |
indicates significant difference as determined by t-tests with Bonferroni correction, p<0.05. nd= not determined.