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Schematic diagram of the translated SARS-CoV genomic RNA in which the open reading frames encoding the viral replicase polyproteins, pp1a and pp1ab, are depicted. The 3 sites recognized and processed by PLpro (red) and the 11 sites recognized and processed by 3CLpro (blue) are indicated. Complete processing of the 14 sites produces16 non-structural proteins (nsp’s). Transmembrane regions are indicated as “TM”, and the polymerase (Pol) and helicase (Hel) coding regions are indicated.
