. Author manuscript; available in PMC: 2013 Apr 7.

Published in final edited form as: Molecules. 2012 Jul 10;17(7):8312–8333. doi: 10.3390/molecules17078312

Table 1.

Multifunctionality of triazole based compounds.

Cpd	Log P	BACE1		Anti-Aβ aggregation		Fe chelation		DPPH

		% Inhibition (at 25 μM) (±SEM)	IC₅₀ (μM)	% Inhibition (at 100 μM) (±SEM)	IC₅₀ (μM)	% Capacity (at 100 μM) (±SEM)	Stoichiometric ratio (Fe:cpd)	% Inhibition (at 100 μM) (±SEM)	IC₅₀ (μM)
6a	4.69	67.95 (±0.35)	19.82	NA	-	9.67 (±0.32)	-	NA	-
6b^a	3.86	73.63 (±1.47)	18.86	7.19 (±1.19)	-	12.35 (±0.68)	-	NA	-
6c	4.10	78.91 (±2.83)	18.03	10.12 (±0.86)	-	15.88 (±0.21)	-	NA	-
6d	3.01	14.10 (±1.79)	-	NA	-	32.86 (±0.19)	-	2.81 (±0.37)	-
6e	2.16	12.57 (±1.10)	-	NA	-	20.63 (±0.35)	-	5.45 (±0.33)	-
6f	1.41	21.28 (±1.92)	-	NA	-	5.80 (±0.04)	-	NA	-
6g	2.01	21.14 (±1.13)	-	66.36 (±2.02)	82.90	8.88 (±0.25)	-	47.03 (±0.12)	106.41

6h	1.75	21.72 (±0.33)	-	84.13 (±2.49)	29.86	42.74 (±0.30)	1:3	92.29 (±0.02)	42.91

12a	4.42	18.91 (±0.40)	-	17.81 (±0.86)	-	42.65 (±1.07)	-	NA	-
12b	3.58	30.42 (±3.54)	-	34.02 (±10.13)	-	10.54 (±0.22)	-	NA	-

12c	3.83	61.46 (±1.83)	20.75	67.56 (±0.72)	83.23	60.90 (±0.51)	1:3	NA	-

12d	2.73	32.97 (±0.37)	-	82.52 (±1.26)	47.51	13.87 (±0.59)	-	1.56 (±0.51)	-
12e	1.88	7.53 (±1.79)	-	36.03 (±1.92)	-	41.42 (±1.13)	-	NA	-
12f	1.13	16.57 (±2.91)	-	3.80 (±1.56)	-	13.06 (±0.16)	-	1.32 (±0.78)	-
12g	1.74	16.23 (±0.45)	-	46.06 (±1.63)	109.83	77.70 (±0.67)	1:3	40.79 (±0.31)	130.44

12h	1.47	40.03 (±0.95)	-	81.48 (±2.54)	56.39	66.45 (±0.37)	1:3	50.58 (±0.17)	92.70

Inh IV (Merck^®)	1.23	96.51 (±1.33)	0.015^b	-	-	-	-	-	-
Curcumin	2.56	-	-	82.90 (±0.82)	0.63^c	-	-	-	-
EDTA	−2.69	-	-	-	-	98.00 (±0.34)		-	-
Ascorbic acid	−3.36	-	-	-	-	-	-	53.64 (±0.11)	94.92

NA = no activity, previously synthesized compounds [8];

Ref. [19];

Ref. [20].