. Author manuscript; available in PMC: 2014 Jul 1.

Published in final edited form as: Ann Noninvasive Electrocardiol. 2013 May 3;18(4):389–398. doi: 10.1111/anec.12050

Table III.

OC and QTc by Generation, Dose, and Route of Delivery

	Number of women	QTc +/− SD	p-value^*	p-value^**

OC generation
First	15, 719	400.8 +/− 21.5	p<0.0001	p<0.0001
Second	9,303	399.2 +/− 21.0
Third	5,762	400.8 +/− 21.1
Fourth	3,890	403.5 +/− 22.6
Non-users	376,106	403.5 +/− 22.6

OC Dose
Very Low	571	402.0 +/− 21.1	p<0.0001	0.1866
Low	33,747	400.7 +/− 21.3
Moderate	157	402.7 +/− 20.8
Non-users	376,106	403.5 +/− 22.6

Route
Oral	34,118	400.7 +/− 21.3	p<0.0001	0.4942
Transdermal	360	401.3 +/− 21.4
Vaginal	198	402.4 +/− 23.8
Non-users	376,106	403.5 +/− 22.6

OC = oral contraceptive use, QT_c = corrected QT,

Includes women not on OC (OC non-users) in analysis,

^**

Includes only women on OC in analysis