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. Author manuscript; available in PMC: 2013 Apr 4.
Published in final edited form as: Cell Mol Life Sci. 2008 Sep;65(17):2637–2657. doi: 10.1007/s00018-008-8086-2

Figure 4.

Figure 4

General domain structure of the CaM-kinases. The conserved CaM-kinase domains are shown in gray (catalytic domains), white (autoinhibitory domains) and black (CaM-binding domains). The catalytic domain of CaMKIII is diagonally hatched, because it bears little resemblance to the other CaM-kinase catalytic domains. The C-terminal association domain of CaMKII and the eEF-2 recognition domain in CaMKIII are shown as white with black dots and white with horizontal black lines, respectively. Note the general domain organization with an N-terminal catalytic domain followed by a regulatory region that contains overlapping autoinhibitory and CaM-binding domains.