Figure 2. Gross alteration of organellar ultrastructure is limited to the GAand to tissues lacking Ube3a.

(A) Comparable morphologies of the peripheral endoplasmic reticulum (ER, e), and nuclear envelope (n) in visual cortical neurons from wildtype, UBE3A^m−/p+, and UBE3A^−/− mice. Scale bars, 500 nm. (B) Immunoblot analysis of Ube3a expression in brain and kidney of wildtype, UBE3A^m−/p+, and UBE3A^−/− mice. (C) Electron micrographs of GAin wildtype, UBE3A^m−/p+, and UBE3A^−/− kidney. Note the GAswelling in UBE3A^−/− kidney (asterisk) and the unaltered GAmorphology in UBE3A^m−/p+ kidney. Scale bars, 500 nm.