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. Author manuscript; available in PMC: 2013 Aug 28.
Published in final edited form as: J Neurosci. 2013 Feb 27;33(9):4165–4180. doi: 10.1523/JNEUROSCI.4185-12.2013

Figure 6. Cxcr4 is downregulated in the DG of Nestin-Cre;Tbr2flox/flox mice.

Figure 6

(A–D) Cxcl12 expression is apparent in the meninges in the hippocampal fissure (HF) in both control and Nestin-Cre;Tbr2flox/flox mice at E16.5 and P0. Expression of Cxcl12 on a per cell basis appears normal in Nestin-Cre;Tbr2flox/flox mice at both ages, although reduction of the HF and decreased numbers of Cxcl12 expressing cells in the HF are readily apparent in mutants. (E–H) Cxcr4, the receptor for Cxcl12 that is expressed on migrating progenitors and neuroblasts, is downregulated in the DG of Nestin-Cre;Tbr2flox/flox mice in comparison to controls at both E16.5 and P0. Scale bar: A = 100 μm.