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. Author manuscript; available in PMC: 2013 Apr 26.
Published in final edited form as: Int J Clin Pharmacol Ther. 2012 Mar;50(3):162–184. doi: 10.5414/CP201484

Figure 8.

Figure 8

A) Changes over baseline in percent 13–30 Hz spectral power in relation to plasma lorazepam concentration in a human volunteer. The direction of increasing time goes along the path from the top right to the bottom left and demonstrates a counter-clockwise hysteresis. B) Changes over baseline in percent 13–30 Hz spectral power in relation to hypothetical effect-site lorazepam concentration in the same subject, where the solid line represents the sigmoid Emax model of the data (data obtained and figure adapted from [117]).