ATX reduces lidocaine inhibition of CA3 Na currents. A, B, Na currents elicited in CA3 cells in 150 mM extracellular Na, in control (A) or in ATX (B). Conditioning voltage: thin black line, −30 mV; gray line, 0 mV; thick black line, +60 mV. C, Na channel availability during test step, normalized to reference in control without lidocaine (gray) or with lidocaine (black). Control, solid lines, ATX (dotted lines). D, Percentage lidocaine inhibition (baseline-subtracted) in control (black, n = 7) and ATX (dotted, n = 7).