Table 4.
Inhibitory effects of compounds on other AKR1C enzymes.
| IC50 Values (μM)
| ||||
|---|---|---|---|---|
| a Compds | AKR1C3 | AKR1C1 | AKR1C2 | AKR1C4 |
| 2 | 0.16 | >100 ( > 625) | 54.50 (336) | >100 ( > 625) |
| 3 | 0.12 | 100 (833) | 40.74 (329) | 49.75 (415) |
| 5 | 0.27 | >100 ( > 370) | 35.73 (134) | >100 ( > 370) |
| 15 | 0.74 | >100 ( > 135) | 81.0 (108) | >100 ( > 135) |
| 16 | 0.22 | >100 ( > 455) | 57.0 (257) | >100 ( > 455) |
| 20 | 0.96 | >100 (> 100) | 100 (100) | 48.7 (357) |
| 27 | 0.21 | >100 (> 478) | 50.13 (240) | >100 (> 478) |
| 44 | 0.13 | 17.73 (136) | 14.45 (111) | 3.51 (27) |
| 47 | 0.09 | 30.71 (341) | 49.57 (538) | 1.95 (22) |
| 50 | 0.34 | 100 (296) | 93.0 (275) | 12.64 (37) |
| 61 | 0.16 | 76.25 (477) | 53.50 (331) | 3.15 (20) |