Skip to main content
. Author manuscript; available in PMC: 2013 Apr 29.
Published in final edited form as: J Neurosci. 2012 Apr 4;32(14):4867–4877. doi: 10.1523/JNEUROSCI.5650-11.2012

Figure 4. Absence of RKIP accelerates the rate of reentrainment to an 8 h advanced LD cycle.

Figure 4

A, B, Representative double-plotted activity profiles of RKIP+/+ (A) and RKIP−/− (B) mice that were stably entrained to an initial fixed LD cycle for at least 2 weeks. Subsequently, the LD cycle was advanced by 8 h and mice were maintained under the new light cycle until they were stably entrained for a minimum of 10 d. Periods of darkness are shaded in gray. y-axis indicates the nth day of study. x-axis indicates time in hours. C, Quantification of the rate of reentrainment to an 8 h advanced LD cycle. Values represent mean ± SEM (hours) cumulative phase shift on each day after the change in the LD cycle. Positive values indicate a phase advance. n = 7 per group. *p < 0.05 vs RKIP+/+ controls.